{"id":377,"date":"2015-06-10T08:08:42","date_gmt":"2015-06-10T07:08:42","guid":{"rendered":"http:\/\/wp.cs.ucl.ac.uk\/gift-surg-intranet\/?p=377"},"modified":"2015-06-10T08:08:42","modified_gmt":"2015-06-10T07:08:42","slug":"fetal-sheep-model-of-spina-bifida-feb-2015","status":"publish","type":"post","link":"https:\/\/wp1.cs.ucl.ac.uk\/gift-surg-intranet\/2015\/06\/10\/fetal-sheep-model-of-spina-bifida-feb-2015\/","title":{"rendered":"fetal sheep model of spina bifida-Feb 2015"},"content":{"rendered":"<p>Since December 2014, our project entitled \u201cReducing invasiveness of fetal SB repair \u2013 towards novel surgical approach and instrumentation\u201d has obtained approval of the institutional Ethics Committee of our university KU Leuven (number P285-2014).<\/p>\n<p>In our Academic Department Development and Regeneration, Biomedical Sciences, Organ Systems, at the faculty of Medicine, with my colleague Alexander Engels, we have experimentally partially reproduced, in a pilot study of 6 pregnant ewes, the fetal lamb model of open spina bifida by surgical induction at 100 days of gestation (Meuli-1995).<\/p>\n<p>The technique requires a midline laparotomy and 6-7 cm hysterotomy under general anesthesia. Afterward the fetal surgery performed on six 1000-gram fetuses consists of a large fetal lumbar skin resection, paraspinal muscle resection, 4-level L1-L4 laminectomy and dura mater resection (Fig below).<\/p>\n<p><a href=\"http:\/\/wp1.cs.ucl.ac.uk\/gift-surg-intranet\/wp-content\/uploads\/sites\/14\/2015\/06\/Screen-Shot-2015-06-03-at-14.57.35.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-517\" src=\"http:\/\/wp1.cs.ucl.ac.uk\/gift-surg-intranet\/wp-content\/uploads\/sites\/14\/2015\/06\/Screen-Shot-2015-06-03-at-14.57.35-300x152.png\" alt=\"Screen Shot 2015-06-03 at 14.57.35\" width=\"300\" height=\"152\" srcset=\"https:\/\/wp1.cs.ucl.ac.uk\/gift-surg-intranet\/wp-content\/uploads\/sites\/14\/2015\/06\/Screen-Shot-2015-06-03-at-14.57.35-300x152.png 300w, https:\/\/wp1.cs.ucl.ac.uk\/gift-surg-intranet\/wp-content\/uploads\/sites\/14\/2015\/06\/Screen-Shot-2015-06-03-at-14.57.35-250x127.png 250w, https:\/\/wp1.cs.ucl.ac.uk\/gift-surg-intranet\/wp-content\/uploads\/sites\/14\/2015\/06\/Screen-Shot-2015-06-03-at-14.57.35.png 691w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Since December 2014, our project entitled \u201cReducing invasiveness of fetal SB repair \u2013 towards novel surgical approach and instrumentation\u201d has obtained approval of the institutional Ethics Committee of our university KU Leuven (number P285-2014). In our Academic Department Development and<\/p>\n","protected":false},"author":35,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"class_list":["post-377","post","type-post","status-publish","format-standard","hentry","category-electronic-journal"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>fetal sheep model of spina bifida-Feb 2015 - GIFT-Surg Intranet<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/wp1.cs.ucl.ac.uk\/gift-surg-intranet\/2015\/06\/10\/fetal-sheep-model-of-spina-bifida-feb-2015\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"fetal sheep model of spina bifida-Feb 2015 - GIFT-Surg Intranet\" \/>\n<meta property=\"og:description\" content=\"Since December 2014, our project entitled \u201cReducing invasiveness of fetal SB repair \u2013 towards novel surgical approach and instrumentation\u201d has obtained approval of the institutional Ethics Committee of our university KU Leuven (number P285-2014). In our Academic Department Development and\" \/>\n<meta property=\"og:url\" content=\"https:\/\/wp1.cs.ucl.ac.uk\/gift-surg-intranet\/2015\/06\/10\/fetal-sheep-model-of-spina-bifida-feb-2015\/\" \/>\n<meta property=\"og:site_name\" content=\"GIFT-Surg Intranet\" \/>\n<meta property=\"article:published_time\" content=\"2015-06-10T07:08:42+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/wp1.cs.ucl.ac.uk\/gift-surg-intranet\/wp-content\/uploads\/sites\/14\/2015\/06\/Screen-Shot-2015-06-03-at-14.57.35-300x152.png\" \/>\n<meta name=\"author\" content=\"lucjoyeux\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"lucjoyeux\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/wp1.cs.ucl.ac.uk\\\/gift-surg-intranet\\\/2015\\\/06\\\/10\\\/fetal-sheep-model-of-spina-bifida-feb-2015\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/wp1.cs.ucl.ac.uk\\\/gift-surg-intranet\\\/2015\\\/06\\\/10\\\/fetal-sheep-model-of-spina-bifida-feb-2015\\\/\"},\"author\":{\"name\":\"lucjoyeux\",\"@id\":\"https:\\\/\\\/wp1.cs.ucl.ac.uk\\\/gift-surg-intranet\\\/#\\\/schema\\\/person\\\/b9780f77e7914a5fcf5ddd145e1dabd3\"},\"headline\":\"fetal sheep model of spina bifida-Feb 2015\",\"datePublished\":\"2015-06-10T07:08:42+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/wp1.cs.ucl.ac.uk\\\/gift-surg-intranet\\\/2015\\\/06\\\/10\\\/fetal-sheep-model-of-spina-bifida-feb-2015\\\/\"},\"wordCount\":131,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/wp1.cs.ucl.ac.uk\\\/gift-surg-intranet\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/wp1.cs.ucl.ac.uk\\\/gift-surg-intranet\\\/2015\\\/06\\\/10\\\/fetal-sheep-model-of-spina-bifida-feb-2015\\\/#primaryimage\"},\"thumbnailUrl\":\"http:\\\/\\\/wp1.cs.ucl.ac.uk\\\/gift-surg-intranet\\\/wp-content\\\/uploads\\\/sites\\\/14\\\/2015\\\/06\\\/Screen-Shot-2015-06-03-at-14.57.35-300x152.png\",\"articleSection\":[\"Electronic Journal\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/wp1.cs.ucl.ac.uk\\\/gift-surg-intranet\\\/2015\\\/06\\\/10\\\/fetal-sheep-model-of-spina-bifida-feb-2015\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/wp1.cs.ucl.ac.uk\\\/gift-surg-intranet\\\/2015\\\/06\\\/10\\\/fetal-sheep-model-of-spina-bifida-feb-2015\\\/\",\"url\":\"https:\\\/\\\/wp1.cs.ucl.ac.uk\\\/gift-surg-intranet\\\/2015\\\/06\\\/10\\\/fetal-sheep-model-of-spina-bifida-feb-2015\\\/\",\"name\":\"fetal sheep model of spina bifida-Feb 2015 - 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